Anakinra is a biologic medication used to treat rheumatoid arthritis and other inflammatory diseases.
A CD30-directed antibody-drug conjugate called brentuximab vedotin is used to treat different lymphomas.
For adults with few other treatment options, the drug cefiderocol has been developed to treat infections brought on by aerobic Gram-negative organisms that are multi-drug (MDR) or extensively drug (XDR) resistant.
The antiapoptotic protein BCL-2 is selectively and orally bioavailability inhibited by the small molecule Venetoclax. It has been shown that overexpression of BCL-2 in CLL cells mediates tumor cell survival. Venetoclax helps restore the apoptotic process by directly binding to the BCL-2 protein
Daratumumab and hyaluronidase are now used together or in combination to assist patients with certain types of multiple myeloma or light chain amyloidosis. It is also being researched as a treatment for other forms of cancer.
Nelarabine is a chemotherapeutic drug used to treat T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma. It is marketed under the trade names Arranon (US) and Atriance (EU) (T-LBL).
Adult patients with triple-negative breast cancer are treated with the cancer drug trodelvy. When surgical removal of the cancer is not possible because it has spread to nearby tissues or to the body as a whole (locally progressed cancer), this treatment is used (metastatic ).
Mitotane is a steroidogenesis inhibitor and cytostatic antineoplastic drug that is used to treat adrenocortical cancer and Cushing’s disease. It is marketed under the trade name Lysodren. Its primary applications are in individuals with metastatic disease.
A combination antibiotic drug called ceftolozane/tazobactam, marketed under the trade name Zerbaxa, is used to treat difficult urinary tract infections and complicated intra-abdominal infections in adults.