Defibrotide sodium

Defibrotide sodium

 

Severe Veno-Occlusive Disease (VOD) Treatment

Molecular Name: Defibrotide sodium

Active Ingredient: Defibrotide sodium
Strength: 80 mg/mL

List of Excipients: Sodium hydroxide (for pH adjustment), hydrochloric acid (for pH adjustment), water for injection.

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Why is Kineret injection prescribed?

The prescription medicine KINERET (anakinra), commonly known as an interleukin-1 receptor antagonist (IL-1Ra), is only available to adults over the age of 18 to:

  • Reduce the signs and symptoms of moderate to severe active rheumatoid arthritis (RA) and slow the damage it causes.
  • To treat people with a form of Cryopyrin-Associated Periodic Syndromes (CAPS) called Neonatal-Onset Multisystem Inflammatory Disease (NOMID)
  • To treat people with Deficiency of Interleukin-1 Receptor Antagonist (DIRA)

To administer Kineret, a subcutaneous injection is used.

Kineret is provided in a graduated prefilled syringe and is ready for use. Using the graduated prefilled syringe, doses between 20 and 100 mg are possible. The syringe is inappropriate for pediatric patients with a body weight below 10 kg because the minimum dose is 20 mg.

Who should not take KINERET?

  • Individuals with allergies to proteins produced by the E. coli bacteria.
  • Individuals with allergies to any component of KINERET, including anakinra. A complete list of KINERET's ingredients can be seen at the end of the patient information sheet.
  • Women who are pregnant or breastfeeding.

If you’re unsure, speak with your doctor.

What are the possible side effects of KINERET?

Severe possible side effects of KINERET include:

  • Allergic reactions
  • Fever or chills
  • Headache
  • Nausea and Vomiting
  • Diarrhea
  • Joint pain
  • Fever
  • Feeling like you have the flu
  • Sore throat or runny nose
  • Sinus infection
  • Redness, Bruising, Swelling, and Pain
  • Urinary tract infection
  • Pain in your stomach area

What documents are required to import KINERET to Dubai?

Individual Patients or hospitals may import Kineret 100 mg at a reasonable price
The following paperwork is necessary to import:
  • An authentic prescription from a licensed physician.
  • Diagnostic reports for patients
  • Patients id proof (Certificate of Origin)

Special Precautions For Kineret

  • Anakinra is sold in graduated prefilled syringes at a reasonable injection cost.
  • Kineret is a sterile, unpreserved fluid. For one use only.
  • Keep in the refrigerator at 2 to 8 degrees Celsius.
  • Avoid freezing.
  • To protect against light, keep it in the original container.
  • The prefilled syringe shouldn't be shaken.
  • For ambulatory use, Kineret may be left out of the fridge for up to 12 hours at a temperature no higher than 25 °C without going past the expiration date.
  • The product must be thrown off once this time has passed instead of returning it to the refrigerator.
  • Before using the solution, visually inspect it for contaminants and discolouration.
  • It is only advised to inject transparent, colourless to white solutions that may contain a few translucent to white amorphous particles from the substance itself.
  • The existence of these particles has no impact on the product's quality.
  • Following local legislation, waste and unneeded pharmaceuticals should be disposed of.

Defibrotide sodium is an anticoagulant medication used to treat severe veno-occlusive disease (VOD) in people who have undergone hematopoietic stem-cell transplantation (HSCT). VOD is a rare and potentially life-threatening complication that can occur after HSCT. Defibrotide sodium works by reducing blood clotting and improving blood flow in the liver. It is administered through intravenous injection.

Special Storage Precautions: Store below 25°C. Do not freeze. Protect from light.

Key Features:

  • Defibrotide sodium is an anticoagulant medication used to treat severe veno-occlusive disease (VOD) in people who have undergone hematopoietic stem-cell transplantation (HSCT).
  • VOD is a rare and potentially life-threatening complication that can occur after HSCT.
  • Defibrotide sodium works by reducing blood clotting and improving blood flow in the liver.
  • It is administered through intravenous injection.
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FAQ's

  • You should not use Defibrotide sodium if you are allergic to it.
  • You should not use defibrotide if you have active bleeding or a history of bleeding in the brain.
  • Store below 25°C. Do not freeze. Protect from light.
  • Defibrotide sodium is effective in treating severe veno-occlusive disease (VOD) in people who have undergone hematopoietic stem-cell transplantation (HSCT).
  • Defibrotide sodium is administered through intravenous injection.
  • The recommended dosage for adults and children weighing more than 40 kg is 6.25 mg/kg every 6 hours for at least 21 days.
  • Common side effects may include bleeding, low blood pressure, nausea, vomiting, diarrhea, headache, fever, or chills.
  • Serious side effects may include bleeding in the brain or other parts of the body.