Mitotane

Molecular Name: Mitotane
Active Ingredient: Mitotane
Dosage Form: 500mg
Manufacturer Name:

Mitotane is a steroidogenesis inhibitor and cytostatic antineoplastic drug that is used to treat adrenocortical cancer and Cushing’s disease. 

Its primary applications are in individuals with metastatic disease, those who cannot undergo surgery, or those who have persistent disease after surgical resection.

Since its primary action is adrenal suppression, Mitotane should be temporarily stopped as soon as a shock or severe trauma occurs. In such cases, exogenous steroids should be given since the depressed adrenal may not quickly begin to secrete steroids. 

Patients with liver illness other than metastatic lesions from the adrenal cortex should use Mitotane with caution since the drug’s metabolism may be disrupted and it may build up.

Before Mitotane administration is started, all potential tumor tissues should be surgically removed from large metastatic masses. This is required to reduce the likelihood of tumor infarction and hemorrhage caused by the drug’s quick cytotoxic action.

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How Darzalex faspro can benefit people?

Darzalex or Darzalex Faspro has been studied in both newly diagnosed and relapsed/refractory multiple myeloma patients. Darzalex/Darzalex Faspro studies in myeloma patients have included the mentioned patient populations:

  • Patients who have previously received multiple therapies (heavily pre-treated)
  • Patients with impaired renal function (renal impairment)
  • Patients who are not candidates for stem cell transplantation
  • Patients who had failed both PIs and IMiDs
  • Patients who have mildly impaired liver function (mild hepatic impairment)

Mechanism of Working

In myeloma cells, the drug Darzalex Faspro interacts to the protein CD38 (this protein is also found on other cells, such as red blood cells). It is believed to reduce the growth of myeloma cells in a number of ways, including by assisting the immune system in finding and eliminating myeloma cells.

A monoclonal antibody called Darzalex can be given to patients in one of two ways: either as an intravenous (IV) infusion or as a subcutaneous (SC) injection (that is, under the skin).

What could be the possible side effects of Darzalex Faspro?

When a patient has an adverse reaction to an infusion, their Darzalex Faspro infusion is stopped, and their symptoms are handled. The infusion may be restarted at a slower rate after the symptoms go away. Those who have several severe responses or a life-threatening infusion reaction stop using Darzalex.

Low neutrophil, platelet, lymphocyte, red blood cell, and haemoglobin counts are the most frequent significant adverse effects. Other issues include:

  • Exhaustion
  • Nausea, vomiting, diarrhoea, or constipation
  • Joint ache or back discomfort
  • Spasms of muscles
  • Fever, chills, vertigo, or sleeplessness
  • Cough
  • Breathing difficulty
  • Hands or lower legs swelling
  • Tingling, prickling, or numbness in the hands and feet (peripheral sensory neuropathy)
  • A higher respiratory infection

About Us

HAYAT ALHIKMAH, a pharmaceutical consultant in Dubai, is here to assist you in fulfilling all your medical requirements. We can assist in procuring medicines like Mitotane. We offer quality assurance.

We have a strong commitment to consult in availing the highest-quality pharmaceuticals and medications. Our team is here to help you every step of the way and make sure that your requirements get fulfilled as soon as possible. Our team of specialists are extremely skilled and knowledgeable about various medications. 

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FAQ's

If you are pregnant, do not take Mitotane. This medication may harm the unborn child or result in miscarriage or premature birth.

Bottles should be stored at 25°C (77°F), with excursions allowed between 15°C and 30°C (59°F-86°F). Mitotane is a cytotoxic medication.

There is a clear link between mitotane plasma levels and antineoplastic efficacy. In particular, plasma levels above 14 mg/L resulted in an objective response rate of up to 55-66%, whereas lower levels predicted lower efficacy.

Mitotane is an antineoplastic (anticancer) medication used to treat adrenal gland cancer. The recommended starting dose of Mitotane is 2 g to 6 g orally, divided into three or four doses per day. Increase the dose gradually until the blood concentration reaches 14 to 20 mg/L or as tolerated.

Lysodren commonly causes the following side effects: 
• Dizziness
• vertigo
• drowsiness
• tiredness
• nausea
• vomiting
• diarrhoea
• loss of appetite
• headache
• unusual weakness
• depression
• skin rash