Brand Name: Zerbaxa
Active Ingredient: Ceftolozane/tazobactam
Dosage Form: 1.5g
Manufacturer Name: Merck Sharp & Dohme B.V.
A combination antibiotic drug called ceftolozane/tazobactam, marketed under the trade name Zerbaxa, is used to treat difficult urinary tract infections and complicated intra-abdominal infections in adults. A cephalosporin antibiotic called ceftolozane was created to treat infections caused by gram-negative bacteria that are resistant to traditional antibiotics.
Ceftolozane is a particular class of antibiotic known as cephalosporin, which is a part of the larger class of drugs known as beta-lactams. It functions by obstructing the synthesis of chemicals required by bacteria to construct their protective cell walls. As a result, the bacterial cell walls become weak and more prone to collapsing, which ultimately results in bacterial death.
How Darzalex faspro can benefit people?
Darzalex or Darzalex Faspro has been studied in both newly diagnosed and relapsed/refractory multiple myeloma patients. Darzalex/Darzalex Faspro studies in myeloma patients have included the mentioned patient populations:
- Patients who have previously received multiple therapies (heavily pre-treated)
- Patients with impaired renal function (renal impairment)
- Patients who are not candidates for stem cell transplantation
- Patients who had failed both PIs and IMiDs
- Patients who have mildly impaired liver function (mild hepatic impairment)
Mechanism of Working
In myeloma cells, the drug Darzalex Faspro interacts to the protein CD38 (this protein is also found on other cells, such as red blood cells). It is believed to reduce the growth of myeloma cells in a number of ways, including by assisting the immune system in finding and eliminating myeloma cells.
A monoclonal antibody called Darzalex can be given to patients in one of two ways: either as an intravenous (IV) infusion or as a subcutaneous (SC) injection (that is, under the skin).
What could be the possible side effects of Darzalex Faspro?
When a patient has an adverse reaction to an infusion, their Darzalex Faspro infusion is stopped, and their symptoms are handled. The infusion may be restarted at a slower rate after the symptoms go away. Those who have several severe responses or a life-threatening infusion reaction stop using Darzalex.
Low neutrophil, platelet, lymphocyte, red blood cell, and haemoglobin counts are the most frequent significant adverse effects. Other issues include:
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Zerbaxa is not recommended for patients who have a history of severe hypersensitivity to ceftolozane/tazobactam, piperacillin/tazobactam, or other beta-lactams.
Zerbaxa is stable for 24 hours when stored at room temperature or 7 days when stored under refrigeration at 2 to 8°C (36 to 46°F) after dilution with 0.9% sodium chloride or 5% dextrose. Zerbaxa solution or diluted Zerbaxa infusion should never be frozen.
Zerbaxa successfully treated the infection in approximately 85% of cases (288 of 340), compared to 75% (266 of 353) of those who received another antibiotic called levofloxacin.
To prevent the development of drug-resistant bacteria and maintain the efficacy of Zerbaxa and other antibacterial medications, Zerbaxa should only be used to treat infections that are proven or strongly suspected to be caused by susceptible bacteria.
Zerbaxa (ceftolozane/tazobactam) for Injection, 1.5 g (1 g/0.5 g) for patients 18 years of age and older with CrCl greater than 50 mL/min.
• breathing problems
• swelling of the face lips
• tongue or throat
• excruciating stomach pain
• bloody or watery diarrhoea
• little to no urination
• ankle or foot edoema
• shortness of breath
• sudden numbness or weakness
• vision or speech problems are all possible side effects.